Villanova vs. Penn State Week Betting Odds: Nittany Lions Roar to No. 6 in Polls

Posted By Katie Kohler on September 20, 2021 - Last Updated on September 24, 2021

We are…playoff contenders? Maybe. Happy Valley hosted Auburn and a White Out crowd in primetime on Saturday and the Penn State Nittany Lions did not disappoint. They beat Auburn 28-20 to advance to 3-0 on the season. They also covered the 5.5-point spread.

The win moved Penn State from No. 10 to No. 6 in the AP Top 25 Poll. The Nittany Lions National title improved from +6000 during the preseason to +3000.

The Nittany Lions host the Villanova Wildcats on Sept. 25 at 12:00 ET. Early in the week, it was hard to find the matchup listed on sports betting apps. Villanova is an FCS opponent so the game might not be up at most sportsbooks until the end of the week. On Thursday morning, it was on Unibet PA sportsbook and DraftKings with Penn State gvas a 30.5-point favorite and the total points line at 54.5.

Villanova vs. Penn State betting lines, odds and preview

Penn State betting info and stats

  • The Nittany Lions are 3-0 ATS this season.
  • None of Penn State’s three games so far have hit the OVER for total points.
  • Villanova is 3-0. They beat their opponents by a combined score of 136-33.

Ways to bet on college football in Pennsylvania

Pennsylvania is home to thirteen legal and regulated sports betting apps. There, you can bet on Penn State college football in various ways such as:

  • Spread
  • Moneyline
  • Total
  • Live/in-game betting
  • 1st half spread, moneyline, total,
  • Quarters

Player props for college football are not offered at Pennsylvania sportsbooks. So, you won’t see lines for “Sean Clifford over/under passing yards.”

College Football promos at Pennsylvania sportsbooks


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  • Parlay boost: Get a 33% profit boost on any 3-leg college football parlay.


  • Risk free bet: Place your first wager risk-free and receive up to $1,000 back in free bets if it loses.
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Penn State 2021 odds tracker

Penn State over/under win total prior to the start of the season OVER 8.5 (-125)/UNDER 8.5 (+105)

Odds via DraftKings

 PreseasonWeek 2
Week 3
Week 4
Week 5
Week 6
Week 7
National Championsip+6000+5000+5000+3000+3000+2500+7500
Big Ten Title+900+600+650+500+600+500+1400
Big Ten East Division +600+500+400
To make playoffsNo (-4000)
Yes (+1300)
No (-1400)
Yes (+700)
No (-3500)
Yes (+1400)
Sean Clifford Heisman+7500+7500+7500+5000+4000+4000

Complete Week 4 College Football Odds at PA Sportsbooks

Lead photo by Barry Reeger/AP

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Katie Kohler

Katie Kohler is a Philadelphia-area based award-winning journalist. She is the Managing Editor at PlayPennsylvania and covers the Pennsylvania gambling industry with an emphasis on sports betting, online casino/poker and the lottery.

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