Penn State vs. Michigan State Betting Odds: Nittany Lions Favored In Regular Season Finale

Written By Katie Kohler on November 21, 2021 - Last Updated on November 27, 2021
Penn State betting Week 13 Michigan State

Despite 35 players battling flu-like symptoms leading up to their Big Ten matchup with Rutgers, Penn State got a shot in the arm from their freshman quarterback. Christian Veilleux took over for a Sean Clifford and tossed three touchdowns to lead the Nittany Lions to a 28-0 win. Penn State covered the double-digit (18) point spread and the total points (47) went Under.

The Nittany Lions (7-4, 4-4 Big Ten) finish their regular season on Nov. 27 when they visit East Lansing to face No. 12 Michigan State. Spartans running back Kenneth Walker III (+2200) has the fourth-best odds to win the Heisman Trophy.

Michigan State (9-2, 6-2 Big Ten) is coming off a 56-7 drubbing at the hands of Ohio State. The loss dropped the Spartans from No. 7 to No. 12 and dashed any hopes of making the College Football Playoffs.

Sports betting apps have Penn State as 5.5-point underdogs against Michigan State with the total points line at 52.5.

Penn State vs. Michigan State betting lines, odds and preview

Penn State betting info DraftKings vs. Michigan State

  • Penn State is 7-3-1 ATS; Michigan State 7-3-1 ATS
  • Penn State O/U record 2-9; Michigan State O/U 6-5
  • Penn State avg. points for 26.2; Michigan State avg. points for 32.1
  • Penn State avg. points against 15.5; Michigan State avg. points against 25.5

College football player props are not offered at PA sportsbooks. You won’t see markets such as individual player props for over/under passing yards for quarterbacks.

Players to watch for Penn State

  • Sean Clifford has passed for 2599 yards, 17 TDs, and 6 INTs
  • Jahan Dotson hauled in 1054 receiving yards and 10 TDs
  • Keyvone Lee leads the Nittany Lions with 416 rushing yards, 2 TDs

College Football Week 13 National Championship and Heisman futures

Teams with best odds to win the College Football National Championship at BetMGM

  • Georgia -125
  • Ohio State +300
  • Alabama +350
  • Cincinnati +3000
  • Notre Dame +4000
  • Michigan +4000

Players with best odds to win the Heisman Trophy

  • CJ Stroud -200
  • Bryce Young +150
  • Matt Corral +1600
  • Kenneth Walker III +2200
  • Kenny Pickett +4000

College football promos at sports betting apps


  • New user promo: Risk-free first bet up to $1,000. If your first bet loses, you’ll get up to $1,000 back in free bets.


  • New user promo: When you join FanDuel sportsbook and place your first bet, if you lose, you’ll get a refund of up $1,000 in site credit.

Penn State 2021 odds tracker

Penn State over/under win total prior to the start of the season OVER 8.5 (-125)/UNDER 8.5 (+105). They started the season 5-0 and were +3000 win the College Football National Championship.

Penn State 2021 Bowl Projections

What bowl game is Penn State going to and who will be their opponent?

Some projections include

Complete College Football Odds at PA Sportsbooks

Lead photo by Barry Reeger/AP

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Katie Kohler

Katie Kohler is a Philadelphia-area based award-winning journalist and Managing Editor at PlayPennsylvania. Katie especially enjoys creating unique content and on-the-ground reporting in PA. She is focused on creating valuable, timely content about casinos and sports betting for readers. Katie has covered the legal Pennsylvania gambling industry for Catena Media since 2019.

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