Indiana vs. Penn State Betting Odds: Nittany Lions Double-Digit Favorites in Big Ten Opener

Posted By Katie Kohler on September 28, 2021 - Last Updated on October 2, 2021

The Penn State Nittany Lions (4-0) start their Big Ten schedule on Oct. 2 when they host the Indiana Hoosiers (2-2). Penn State is coming off a 38-17 win over FCS opponent Villanova. The Nittany Lions were huge favorites (-29.5) but did not cover for the first time this season.

Penn State moved from No. 6 to No 4 in the AP Top 25.

Indiana vs. Penn State betting lines, odds and preview

Penn State betting info and stats

  • The Nittany Lions are 3-1 ATS this season; Indiana 1-3 ATS
  • Penn State O/U record 1-3; Indiana O/U record 3-1.
  • Dating back to the end of last season, Penn State has won eight straight games.
  • Each of Indiana’s last six road games in October have gone OVER the the total points line
  • Penn State has covered the spread in seven of its last eight games.

Betting splits for Indiana vs. Penn State from DraftKings

  • 84% of the money is on Penn State (12.5)
  • 61% of the money is on the UNDER (53.5)
  • 91% of the money is on Penn State ML (-490)

How to bet on college football in Pennsylvania

There are thirteen legal online sportsbooks in Pennsylvania. You can bet on Penn State college football in a variety ways such as:

  • Spread
  • Moneyline
  • Total
  • Live/in-game betting
  • 1st half spread, moneyline, total,
  • Quarters

However, player props are not offered at PA sportsbooks. You won’t see markets such as individual player props for over/under passing yards for quarterbacks.

College football promos at Pennsylvania sportsbooks


  • Bet $1 get $150: New users who place a $1 wager on a college football game or on the NFL, get $150 in free bets.
  • Parlay boost: Get a 33% profit boost on any 3-leg college football parlay.


  • Risk free bet: Place your first wager risk-free and receive up to $1,000 back in free bets if it loses.
  • One game parlay: Opt-in to the promo and place a $25+ one game parlay on a college football game. Get a $10 free bet to use on live betting for any sport.


  • 20% parlay boost on college football every week

Penn State 2021 odds tracker

Penn State over/under win total prior to the start of the season OVER 8.5 (-125)/UNDER 8.5 (+105)

Odds via DraftKings

 PreseasonWeek 2
Week 3
Week 4
Week 5
Week 6
Week 7
National Championsip+6000+5000+5000+3000+3000+2500+7500
Big Ten Title+900+600+650+500+600+500+1400
Big Ten East Division +600+500+400
To make playoffsNo (-4000)
Yes (+1300)
No (-1400)
Yes (+700)
No (-3500)
Yes (+1400)
Sean Clifford Heisman+7500+7500+7500+5000+4000+4000

Complete Week 5 College Football Odds at PA Sportsbooks

Lead photo by Barry Reeger/AP

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Katie Kohler

Katie Kohler is a Philadelphia-area based award-winning journalist. She is the Managing Editor at PlayPennsylvania and covers the Pennsylvania gambling industry with an emphasis on sports betting, online casino/poker and the lottery.

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