Indiana vs. Penn State Betting Odds: Nittany Lions Double-Digit Favorites in Big Ten Opener

Written By Katie Kohler on September 28, 2021 - Last Updated on October 2, 2021
Indiana vs. Penn State betting preview

The Penn State Nittany Lions (4-0) start their Big Ten schedule on Oct. 2 when they host the Indiana Hoosiers (2-2). Penn State is coming off a 38-17 win over FCS opponent Villanova. The Nittany Lions were huge favorites (-29.5) but did not cover for the first time this season.

Penn State moved from No. 6 to No 4 in the AP Top 25.

Indiana vs. Penn State betting lines, odds and preview

Penn State betting info and stats

  • The Nittany Lions are 3-1 ATS this season; Indiana 1-3 ATS
  • Penn State O/U record 1-3; Indiana O/U record 3-1.
  • Dating back to the end of last season, Penn State has won eight straight games.
  • Each of Indiana’s last six road games in October have gone OVER the the total points line
  • Penn State has covered the spread in seven of its last eight games.

Betting splits for Indiana vs. Penn State from DraftKings

  • 84% of the money is on Penn State (12.5)
  • 61% of the money is on the UNDER (53.5)
  • 91% of the money is on Penn State ML (-490)

How to bet on college football in Pennsylvania

There are thirteen legal online sportsbooks in Pennsylvania. You can bet on Penn State college football in a variety ways such as:

  • Spread
  • Moneyline
  • Total
  • Live/in-game betting
  • 1st half spread, moneyline, total,
  • Quarters

However, player props are not offered at PA sportsbooks. You won’t see markets such as individual player props for over/under passing yards for quarterbacks.

College football promos at Pennsylvania sportsbooks


  • Bet $1 get $150: New users who place a $1 wager on a college football game or on the NFL, get $150 in free bets.
  • Parlay boost: Get a 33% profit boost on any 3-leg college football parlay.


  • Risk free bet: Place your first wager risk-free and receive up to $1,000 back in free bets if it loses.
  • One game parlay: Opt-in to the promo and place a $25+ one game parlay on a college football game. Get a $10 free bet to use on live betting for any sport.


  • 20% parlay boost on college football every week

Penn State 2021 odds tracker

Penn State over/under win total prior to the start of the season OVER 8.5 (-125)/UNDER 8.5 (+105)

Odds via DraftKings

PreseasonWeek 2
Week 3
Week 4
Week 5
Week 6
Week 7
Week 8
Week 10
National Championsip+6000+5000+5000+3000+3000+2500+7500+20000+50,000
Big Ten Title+900+600+650+500+600+500+1400+50,000
Big Ten East Division +600+500+400
To make playoffsNo (-4000)
Yes (+1300)
No (-1400)
Yes (+700)
No (-3500)
Yes (+1400)
Sean Clifford Heisman+7500+7500+7500+5000+4000+4000+20000

Complete Week 5 College Football Odds at PA Sportsbooks

Lead photo by Barry Reeger/AP

Katie Kohler Avatar
Written by
Katie Kohler

Katie Kohler is a Philadelphia-area based award-winning journalist and Managing Editor at PlayPennsylvania. Katie especially enjoys creating unique content and on-the-ground reporting in PA. She is focused on creating valuable, timely content about casinos and sports betting for readers. Katie has covered the legal Pennsylvania gambling industry for Catena Media since 2019.

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