San Francisco 49ers vs. Philadelphia Eagles: Week 2 NFL Betting Preview And Lines – September 19, 2021

Posted By Staff on September 15, 2021 - Last Updated on September 22, 2021

The Philadelphia Eagles (1-0) are 3.5-point underdogs heading into their matchup on Sunday, September 19, 2021 against the San Francisco 49ers (1-0). The over/under is set at 50.

Betting Odds

Favorite Spread Favorite Spread Odds Underdog Spread Odds Total Over Total Odds Under Total Odds
49ers -3.5 -110 -110 50 -105 -115

The betting insights in this article reflect betting data from DraftKings as of September 13, 2021, 12:00 AM ET. CLICK HERE to find current betting odds and place a bet at DraftKings Sportsbook.

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Eagles Leaders

  • A season ago, Miles Sanders churned out 867 rushing yards (54.2 yards per game) and scored six touchdowns.
  • Last season Dallas Goedert was targeted 65 times and recorded 46 catches for 524 yards (43.7 ypg) while scoring three touchdowns.
  • Minshew put together a solid 2020 fantasy season, scoring 159.7 total fantasy points (10.0 per game) to finish 54th overall and 23rd among quarterbacks in the league-wide fantasy rankings.
  • Last year, Sanders finished as the 68th-ranked fantasy player overall and the 20th-ranked running back. He totaled 146.4 fantasy points, averaging 9.2 per game.

Eagles Injuries

Eagles: No Injuries Listed

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Head To Head

49ers vs Eagles: Last Meeting
Date Favorite Home Team Spread Total Favorite Moneyline Underdog Moneyline Total Yards Result
10/4/2020 49ers 49ers -8.5 45.5 -345 +290 417-267 SF 25-20 PHI

Eagles Insights

  • The average points per game for the Eagles last year, 20.9, was 3.5 fewer than the 24.4 the 49ers gave up.
  • In games when Philadelphia scored more than 24.4 points last season, it was 1-3 overall and 2-2 against the spread.
  • San Francisco was 6-0 overall and 6-0 against the spread last year when it allowed fewer than 20.9 points.
  • The Eagles picked up 126.9 rushing yards per game last season, 20.5 more than the 49ers gave up (106.4).

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Eagles Schedule

Date Opponent Score Home/Away Spread
9/12/2021 Falcons W 32-6 Away +3.5
9/19/2021 49ers Home +3.5
9/27/2021 Cowboys Away
10/3/2021 Chiefs Home
10/10/2021 Panthers Away
10/14/2021 Buccaneers Home
10/24/2021 Raiders Away
10/31/2021 Lions Away
11/7/2021 Chargers Home
11/14/2021 Broncos Away
11/21/2021 Saints Home
11/28/2021 Giants Away
12/5/2021 Jets Away
12/19/2021 Washington Home
12/26/2021 Giants Home
1/2/2022 Washington Away
1/9/2022 Cowboys Home

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